About us

Quirem Medical BV

Quirem Medical is an emerging medical device company with a mission to develop the next generation microspheres for selective internal radiotherapy (SIRT) of liver malignancies.

Quirem Medical BV is a spin-off company of the University Medical Center Utrecht (UMCU) and commercializes, manufactures and distributes a new type of SIRT microspheres based on the isotope holmium, named QuiremSpheres®. QuiremSpheres® has received CE mark approval in April 2015 and is currently available in selected markets in Europe. SIRT is an efficacious treatment modality for advanced unresectable liver tumors. We believe that the unique imaging capabilities of holmium microspheres can further drive treatment outcome by tailoring the treatment to the patient.

Quirem Medical’s ambition is to provide a real-time, image guided, personalized SIRT treatment with improved patient outcome, and to lower the hurdles for adoption of SIRT for the treatment of cancer.

Quirem Medical Management team

Jan Sigger

Chief Executive Officer

Jan Sigger held senior management positions at Royal Dutch Shell and Akzo Nobel before joining Nucletron, the global market leader in brachytherapy as CFO in 2008. Between 2008 – 2012 he was instrumental in transforming Nucletron into the fastest growing radiotherapy company and managed the sale from private equity ownership to Elekta AB in 2011. Jan Sigger is a Master in Business Economics and holds a post-graduate degree as Chartered Accountant.

Frank Nijsen

Chief Scientific Officer

Frank Nijsen has performed research into Holmium microspheres for more than 20 years. He has led the successful valorisation of the Holmium technology and was instrumental in the creation of the spin-off company Quirem Medical. He holds as inventor many patents in the field. Frank Nijsen holds a doctorate in Medical Biology and is an Associate Professor at the Radboud University Medical Center.

Quirem Medical Supervisory Board

Peter Coenen

Member of the Board

Peter Coenen has more than 25 years of experience in the medical device area leading and adapting organizations to new market situations to deliver value to customers and the companies he worked for. He started his career in the medical device division of Ely Lilly which then became Guidant. After the acquisition of Guidant by Boston Scientific Peter he was responsible for the legal merger of Guidant and BSX in Japan. He today is a Director and Board member in Terumo Europe responsible for the EMEA region as President of the Interventional business unit.

Tim Irish


Tim Irish has worked in the life sciences industry for thirty years. His career has spanned global health technology companies across Europe and North America, including GSK, GE and Philips. Tim’s current governance portfolio covers Life Sciences, Healthcare and Education, both public and private, including Board roles as Senior Independent Director and NED at National Institute for Health and Care Excellence (NICE), various European MedTech Supervisory Board roles, and Professor of Practice at King’s College London’s School of Management and Business.

Paul Roos

Member of the Board

Paul Roos is a seasoned executive with extensive experience and a proven track record in the international life sciences industry, having spent over 10 years working in investment banking and over five years as a CFO. He currently serves as CFO of Polyganics. Previously Mr. Roos served as CFO of IRX Innovations and as CFO of Synthon. He began his career at the Corporate Finance Division of Kempen & Co, where he his final position was Executive Director in the Life Sciences/ Healthcare team. 


University Medical Center Utrecht

By building on its long term partnership with the University Medical Center Utrecht and supported by a strong patent base, both parties are committed to collaborate in the further development of the Holmium technology base to bring better cancer treatment solutions to patients worldwide.

University Medical Center Utrecht strives to achieve the highest levels in, patient care, scientific research and education. By dedicating ourselves to continuous improvements, we can pioneer cutting-edge treatments, foster groundbreaking findings, and deliver a standard of care that meets the healthcare needs for today, and the future.

Terumo Corporation

On January 29th 2016 Terumo Corporation and Quirem Medical expanded their Strategic Alliance. Terumo thereby became the exclusive global distributor for the radioembolization solutions developed by Quirem Medical.

Tokyo-based Terumo Corporation is one of the world’s leading medical device manufacturers with over $5 billion in sales and operations in more than 160 nations. Founded in 1921, the company develops, manufactures, and distributes world-class medical devices including products for use in interventional procedures, cardiovascular surgery, and transfusion medicine; the company also manufactures a broad array of syringe and hypodermic needle products for hospital and physician office use and also supplies drug delivery/injection devices to pharmaceutical firms. Terumo Corporation’s shares are listed on the first section of the Tokyo Stock Exchange and are a component of the Nikkei, Japan’s leading stock index.

Visit the Terumo QuiremSpheres® product page.