Frank Nijsen has performed research into Holmium microspheres for more than 20 years. He has led the successful valorisation of the Holmium technology and was instrumental in the creation of the spin-off company Quirem Medical. He holds as inventor many patents in the field. Frank Nijsen holds a doctorate in Medical Biology and is currently Associate Professor at the Radboud University Medical Center.

Jan Sigger held senior management positions at Royal Dutch Shell and Akzo Nobel before joining Nucletron, the global market leader in brachytherapy as CFO in 2008. Between 2008 – 2012 he was instrumental in transforming Nucletron into the fastest growing radiotherapy company and managed the sale from private equity ownership to Elekta AB in 2011. Jan Sigger is a Master in Business Economics and holds a post-graduate degree as Chartered Accountant.

Before joining Quirem Medical in 2015 as a Finance Manager, Anet worked with Avantor Performance Materials, a global supplier for the pharmaceutical industry. There she worked in the Finance & Salary Department for 15 years. She has a Bachelor of Economics degree obtained at Hogeschool Arnhem.

Before joining Quirem Medical as Company Secretary, Anneke worked with Avantor Performance Materials, a global supplier of ultrahigh purity life sciences materials for the pharmaceutical industry. She was Management Assistant working for the Management Team. Before that she worked as a Secretary with Recticel Bedding, a company that develops and makes boxsprings and mattresses. Anneke obtained a college diploma as a Management Assistant.

Tayser Yagob has a PhD in radiation chemistry. She has 15 years of experience in the radiation chemistry field, eight years as a research scientist at Sudan Atomic Energy Commission (SAEC) and seven years at the Reactor Institute (RID) of the TU Delft. During her work in SAEC she participated actively as the main researcher and the country coordinator in the execution of technical cooperation projects on health and nutrition in Sudan which supported by the International Atomic Energy Agency (IAEA). She joined TU Delft in 2012 as a PhD researcher, the main task of her research was to evaluate the capability of the neutron activation analysis (NAA) as an isotope ratio measurement technique to be used in the clinical research. After her PhD she continues her research in the same field and same group as a postdoc researcher.

Tayser join Quirem in 2019 as a hot lab controller and research support. She is responsible for controlling the production of the final dose of Ho-166 and supporting the research team.

Stuart Koelewijn holds a bachelor in Biomedical Sciences and has performed research in the field of radionuclide therapy. One of the investigated strategies was to improve existing therapies by combining it with therapy based on holmium microspheres, now known as QuiremSpheres. At this moment, Stuart Koelewijn holds the position of Research Scientist in Chemistry and Radiobiology at Quirem Medical and continues the investigation to optimize treatment through radioembolization and in addition investigate the application of QuiremSpheres for treatment of cancers at various sites.

Before joining Quirem Medical as a product manager, Sander worked with Elekta, a global company creating solutions for treating cancer and brain disorders. Before that Sander worked as Medical Physicist Resident at the Erasmus MC. He has a MSc. degree in Biomedical Engineering and an BSc. degree in Applied Physics, both obtained at the Delft Technical University.

Prior to joining Quirem Medical as Medical Director, Rijk worked at Philips within the Clinical Science department in the Image Guided Therapies division. There he was responsible for clinical evaluations of the supporting software medical devices. Before that, Rijk gained significant experience in designing and conducting clinical trials at Medtronic as a senior Clinical Research Specialist. He has a background in Biomedical Engineering (BSc and MSc), obtained at the University of Twente.

After my Bachelor Life Sciences at the HLO in Utrecht, I worked for 7 years as Research Technician in the Molecular Group of the Cell Biology division at the University Utrecht. I was given the responsibility to set up new assays, to come up with optimization strategies and to use these assays to answer applied research questions. My research topic is on the development of a new immunotherapeutic for brain tumors that express the oncogenic variant EGFRvIII. The goal of this project was to create and characterize a new immunotoxin that can induce apoptosis in glioma’s both in vitro and in preclinical mouse models.

After this experience I worked 4 years as a Team leader Manufacturing Operations at Leica Biosystems in Amsterdam, producing FISH-probes for cancer diagnostics. I was mainly focused on teambuilding, working more efficiently and continuously improving and implementing processes and structures in the department by using Lean tools (DBS).

At Quirem I work as Hotlab Operations Officer. Responsible for the Hotlab sites. Lead in final production of Quirem products as first operator.

Before joining Quirem Medical as Supply Chain Officer, Nezar worked with Boeing B.V at Schiphol Airport as Supply Chain specialist. Nezar has more than 8 years of professional experience working with international organizations in the supply chain, quality management and operations optimization. He has a MSc. Degree in International Management of Sustainable Development from VHL University Netherlands and a BSc. Degree in Industrial Engineering

Having a Master’s degree in Science and Business Management from Utrecht University, Maurice joined Quirem Medical as Jr. Product Manager. He is actively involved in the development of existing and new products. For this purpose, Maurice is operating on the interface between marketing, clinical research, supply chain operations, R&D and regulatory processes.

Working with the unique products of Quirem Medical, the goal of Maurice is to provide better personalized treatments to patients in need.

Before joining Quirem Medical Matthijs worked for Avantor Peformance Materials performing quality control on diagnostics hematological reagents. Apart from having a knack for technology Matthijs also was a member and head of the works council. After joining the Quirem Team Matthijs helped set up production and QC Operations. He currently manages the cold microsphere production team and patient dose logistics.

Having a background in Biomedical Engineering (BSc and MSc) with a specialization in Biotechnologies for Electronics, all obtained at Politecnico di Milano (Italy), Martina joined Quirem Medical as a Research Scientist. She has been recently funded by NWO, through the Industrial Doctorate program, to carry out her PhD at UMC Utrecht, in collaboration with Quirem Medical, aimed at introducing true personalized dosimetry into every day medical practice.

Marloes obtained a BSc degree in Biochemistry at Saxion Hogeschool in 2013. After graduating, Marloes worked at “De Gezondheidsdienst voor Dieren”, Abbott Biologicals and Friesland Campina. In September 2018 Marloes joined Quirem Medcial as a Production & QC Chemist and is working on the production of the Ho-microspheres and the Quality Cotrol on the spheres.

José joined the Quirem Medical Team in September 2018 as a Project Leader. In this role she is dedicated to successfully finish a project. Before joining Quirem, José worked for the Rabobank for 15 years in many positions. The last position was Manager/Project Leader.

John joined Quirem in 2015 and is responsible for quality assurance as well as regulatory affairs. Through his 30 years of experience in quality assurance and quality management functions at Fuji Photo Film BV and Avantor Materials BV, he gained a broad knowledge of Japanese, cGMP and ISO 13485 quality management systems. John holds a doctor’s degree in chemistry and physics.

Jessica joined the Production & QC team in August 2019. Before joining Quirem Medical, she worked at Agendia as a diagnostic technician for 11 years, performing the MammaPrint- and BluePrint test for breast cancer patients.

Before joining Quirem Medical as a Supply Chain Manager, Jerfaas worked at DHL Supply Chain. He was responsible for a wide variety of projects with leading clients in the Life Sciences & Healthcare industry, where quality and delivery performance are crucial. Before that, he gained extensive experience at the logistical service providers Kuehne + Nagel and DB Schenker. Jerfaas has an MBA in Logistics & Supply Chain Management.

Before joining Quirem Medical Ilona obtained a BSc degree in Biochemistry at Saxion Hogeschool. During her graduation assignment she worked on a biomolecular research project into mammary gland tumors of the dog.

Harald joined Quirem to focus his expertise and enthusiasm on medical devices and people’s health. He is responsible for quality assurance and regulatory affairs. He gained extensive knowledge in the field of product safety and regulatory affairs in the Chemical, Food- and Feed industry. His previous employers included BASF, Avebe and Akzo Nobel at which he held several specialist and managerial functions, always with a strong interest and motivation to produce safe products. Another personal drive is to motivate people and optimise multidisciplinary processes together.

Gerrit joined Quirem Medical from the very beginning to set-up imaging and software development activities at the company. He got involved in the holmium microsphere research during his PhD at the UMC Utrecht where his focus was on MRI based dosimetry of holmium radioembolization. He has a MSc. Degree in Applied Physics obtained at the University of Twente.

Having a background in Mechanical Engineering (BEng) and Biomedical Engineering (MSc), Gerhard has a role to support the Quirem team in technical challenges in order to improve the processes for the production of QuiremSpheres.

Before joining Quirem Medical B.V., Gerbert worked for Avantor Performance Materials Deventer as a Chemical Analyst Quality Control.

Gerbert joined the Production & QC team in February 2020.

Having a background in Technical Medicine (BSc), Medical Imaging & Intervention (MSc) and Radiation Expertise level 3, all obtained at University Twente, Feiko has a role to support the Quirem team in imaging solutions for QuiremSpheres as well as training and support of customers.

Esther joined Quirem Medical in September 2018 as a project leader. In this role she works on automating and optimizing the Hot-lab production process of QuiremSpheres. Before that, Esther obtained a BSc degree in Chemistry at Saxion Hogeschool in Deventer.

Having a background in Technical Medicine (BSc) and Medical Imaging & Interventions (MSc) and a knowledge of radioactivity (level 3), all obtained at University Twente, Eline acts as a Clinical Support Officer within Quirem Medical. In that role she is engaged in supporting clinical research, developing clinical marketing materials, post-market surveillance and various other clinical aspects of QuiremSpheres®.

Diana joined Quirem Medical in October 2018 as a member of the production team. Before that she has worked 28 years in an environmental laboratory, as a chemical analyst to analyse the pollution of soil, water and air samples.

Before joining Quirem Medial as R&D Scientist Carla worked with Avantor Performance Materials, a global supplier of ultra-high purity life sciences materials for the pharmaceutical industry. There she worked in the R&D department, giving application support to pharmaceutical industry for all chemicals needed in the production of biomedicines. Before that Carla worked as R&D Analyst at the Radboud University Nijmegen. She has a BSc degree in Biochemistry, obtained at Saxion Hogeschool IJsselland.

Alinde joined the Quirem Medical team in January 2018 as QA/RA support officer. In this role she supports the QA manager and is, among other things, responsible for the document control system.

Before joining Quirem, Alinde worked for Avantor Performance Materials for 19 years, 3 years at the Quality Control department and 16 years at the QA department as QA/RA support officer. She also was an internal ISO-auditor and confidential adviser.

Alexandra has a MSc. Degree in Pharmaceutical Sciences (University of Lisbon) and holds a doctorate degree in physical chemistry (University of Strasbourg). Before joining Quirem, she started developing new holmium medical devices at the UMC Utrecht during a 3-year post-doc. Alexandra joined Quirem in September 2019 as a Senior R&D Scientist and is responsible for the development of novel radioactive medical device products and for the support to new innovative developments in the current medical applications of holmium.